Toxicity due to cisplatin was assessed on rat brain and protective role of turmeric was investigated. A total of 48 rats were divided into 4 groups of 12 rats each. Group 1 was maintained as sham control, 2 was treated with cisplatin (@ 2 mg/kg b.wt, intraperitoneally on day 1, 7, 14 and 28), 3 was treated with turmeric (@ 0.05 mg/kg b.wt. p.o. once daily for 28 days) and 4 was treated with cisplatin + turmeric (as per above schedule). The concentration of thiobarbituric acid reacting substances (TBARS) and protein carbonyls in brain tissue homogenates were significantly (P<0.05) increased and the concentration of reduced glutathione (GSH) was significantly (P<0.05) reduced in group 2 as compared to other groups. Groups 1 and 3 did not reveal significant difference among themselves, while group 4 showed slight improvement compared to group 2.
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